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Article

Characterizing brain metabolic function ex vivo with acute mouse slice punches

23 May 2021

Abstract excerpt

Mitochondrial dysfunction and metabolic reprogramming are implicated in a variety of neurological disorders. Here, we present a protocol that enables complex profiling of brain metabolic function using acute mouse brain slices ex vivo. Utilizing differential metabolic conditions, substrates, and inhibitors, this protocol can be broadly applied to determine metabolic shift or reprogramming upon genetic...

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PMID: 34095867
DOI: 10.1016/j.xpro.2021.100559

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