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Article

Primary Osteocyte Supernatants Metabolomic Profiling of Two Transgenic Mice With Connexin43 Dominant Negative Mutants.

Frontiers in endocrinology - 1 Jan 2021

Chen Meng, Li Guobin, Zhang Lan, Ning Kaiting, Yang Baoqiang, Jiang Jean X, Wang Dong-En, Xu Huiyun

Abstract excerpt

Osteocytes could release some small molecules (≤ 1 kDa) through gap junctions and hemichannels to extracellular environment, such as prostaglandin E2 (PGE2), nitric oxide (NO) and adenosine triphosphate (ATP), which play key roles in transferring signals between bone cells and other tissue cells. Connexin (Cx) 43 is the most abundant connexin in osteocytes. To further discover molecules released by osteocytes...

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Identifiers

PMID: 34093433
DOI: 10.3389/fendo.2021.649994
PMCID: PMC8169970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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