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Article

Cyclophilin D Knock-Out Mice Show Enhanced Resistance to Osteoporosis and to Metabolic Changes Observed in Aging Bone.

PloS one - 1 Jan 2016

Shum Laura C, White Noelle S, Nadtochiy Sergiy M, Bentley Karen L de Mesy, Brookes Paul S, Jonason Jennifer H, Eliseev Roman A

Abstract excerpt

Pathogenic factors associated with aging, such as oxidative stress and hormone depletion converge on mitochondria and impair their function via opening of the mitochondrial permeability transition pore (MPTP). The MPTP is a large non-selective pore regulated by cyclophilin D (CypD) that disrupts mitochondrial membrane integrity. MPTP involvement has been firmly established in degenerative processes in heart,...

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Identifiers

PMID: 27183225
DOI: 10.1371/journal.pone.0155709
PMCID: PMC4868300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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