Article
Comparison of digital PCR systems for the analysis of liquid biopsy samples of patients affected by lung and colorectal cancer.
Clinica chimica acta; international journal of clinical chemistry - 15 Feb 2023
Crucitta Stefania, Ruglioni Martina, Novi Claudia, Manganiello Mascia, Arici Roberta, Petrini Iacopo, Pardini Eleonora, Cucchiara Federico, Marmorino Federica, Cremolini Chiara, Fogli Stefano, Danesi Romano, Del Re Marzia
Abstract excerpt
BACKGROUND AND AIMS: Highly sensitive technologies are available for the molecular characterization of solid tumors, including digital PCR (dPCR). Liquid biopsy, based on the analysis of cell-free DNA (cfDNA), is often used to assess EGFR or RAS alterations in lung and colorectal cancers. Our study aimed to compare the results of two different dPCR platforms for the detection of mutations in cfDNA. METHODS:...
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