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Article

EGFR mutation detection on routine cytological smears of non-small cell lung cancer by digital PCR: a validation study.

Journal of clinical pathology - 1 May 2016

Malapelle Umberto, de Luca Caterina, Vigliar Elena, Ambrosio Francesca, Rocco Danilo, Pisapia Pasquale, Bellevicine Claudio, Troncone Giancarlo

Abstract excerpt

Highly sensitive genotyping techniques are useful to detect epidermal growth factor receptor (EGFR) mutations on lung cancer cytological samples, when these specimens feature only few neoplastic cells. This study aimed to validate digital PCR (dPCR) methodology on cytological material. In plasmid model system, dPCR allowed for the detection of a minimal percentage (1%) of EGFR mutant alleles. Cytological samples...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26893402
DOI: 10.1136/jclinpath-2015-203429

Genes

EGFR

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