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Article

S-Equol mitigates motivational deficits and dysregulation associated with HIV-1.

Scientific reports - 4 Jun 2021

McLaurin Kristen A, Bertrand Sarah J, Illenberger Jessica M, Harrod Steven B, Mactutus Charles F, Booze Rosemarie M

Abstract excerpt

Motivational deficits (e.g., apathy) and dysregulation (e.g., addiction) in HIV-1 seropositive individuals, despite treatment with combination antiretroviral therapy, necessitates the development of innovative adjunctive therapeutics. S-Equol (SE), a selective estrogen receptor β agonist, has been implicated as a neuroprotective and/or neurorestorative therapeutic for HIV-1 associated neurocognitive disorders...

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Identifiers

PMID: 34088932
DOI: 10.1038/s41598-021-91240-0
PMCID: PMC8178385

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