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hTERT Promotes CRC Proliferation and Migration by Recruiting YBX1 to Increase NRF2 Expression

17 May 2021

Abstract excerpt

High human telomerase reverse transcriptase (hTERT) expression is related to severe Colorectal Cancer (CRC) progression and negatively related to CRC patient survival. Previous studies have revealed that hTERT can reduce cancer cellular reactive oxygen species (ROS) levels and accelerate cancer progression; however, the mechanism remains poorly understood. NFE2-related factor 2 (NRF2) is a molecule that plays a...

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PMID: 34079797
DOI: 10.3389/fcell.2021.658101

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