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Article

Similar frequency and signature of untargeted substitutions induced by abasic site analog under reduced human APE1 conditions.

The Journal of toxicological sciences - 1 Jan 2021

Suzuki Tetsuya, Katayama Yuri, Komatsu Yasuo, Kamiya Hiroyuki

Abstract excerpt

Abasic sites are formed in cells by various factors including environmental mutagens and considered to be involved in cancer initiation, promotion, and progression. A chemically stable abasic site analog (tetrahydrofuran-type analog, THF) induces untargeted base substitutions as well as targeted substitution and large deletion mutations in human cells. The untargeted substitutions may be initiated by the cleavage...

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Identifiers

PMID: 34078835
DOI: 10.2131/jts.46.283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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