[Nucleic Acids-based Elucidation of Molecular Mechanisms of Mutagenesis and Development of Gene Therapy Methods].

Abstract excerpt

DNA preserves and inherits genetic information. 7,8-dihydro-8-oxoguanine (GO) and abasic sites are some of the most common DNA lesions generated endogenously in living organisms and they induce mutations. The resultant mutations in our DNA cause diseases such as cancers. GO and abasic sites are known to induce mutations at the positions of the lesions. We revealed GO induced mutations at points distant from a...

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