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Article

α-Synuclein Deposition in Sympathetic Nerve Fibers in Genetic Forms of Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Oct 2021

Isonaka Risa, Goldstein David S, Zhu William, Yoon Esther, Ehrlich Debra, Schindler Alice B, Kokkinis Angela D, Sabir Marya S, Scholz Sonja W, Bandres-Ciga Sara, Blauwendraat Cornelis, Gonzalez-Alegre Pedro, Lopez Grisel, Sidransky Ellen, Narendra Derek P

Abstract excerpt

BACKGROUND: Cytoplasmic inclusions of α-synuclein (α-syn) in brainstem neurons are characteristic of idiopathic Parkinson's disease (PD). PD also entails α-syn buildup in sympathetic nerves. Among genetic forms of PD, the relative extents of sympathetic intraneuronal accumulation of α-syn have not been reported. OBJECTIVE: This cross-sectional observational study compared magnitudes of intraneuronal deposition of...

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Identifiers

PMID: 34076298
DOI: 10.1002/mds.28667
PMCID: PMC9014961

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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