Article
Cycling hypoxia induces a specific amplified inflammatory phenotype in endothelial cells and enhances tumor-promoting inflammation in vivo.
Neoplasia (New York, N.Y.) - 1 Jan 2015
Tellier Céline, Desmet Déborah, Petit Laurenne, Finet Laure, Graux Carlos, Raes Martine, Feron Olivier, Michiels Carine
Abstract excerpt
Abnormal architecture of the tumor blood network, as well as heterogeneous erythrocyte flow, leads to temporal fluctuations in tissue oxygen tension exposing tumor and stromal cells to cycling hypoxia. Inflammation is another feature of tumor microenvironment and is considered as a new enabling characteristic of tumor progression. As cycling hypoxia is known to participate in tumor aggressiveness, the purpose of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.