SLAMF3-Mediated Signaling via ERK Pathway Activation Promotes Aggressive Phenotypic Behaviors in Multiple Myeloma.

doi:10.1158/1541-7786.MCR-19-0391

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Article

SLAMF3-Mediated Signaling via ERK Pathway Activation Promotes Aggressive Phenotypic Behaviors in Multiple Myeloma.

Molecular cancer research : MCR - 1 Apr 2020

Ishibashi Mariko, Takahashi Risa, Tsubota Asako, Sasaki Makoto, Handa Hiroshi, Imai Yoichi, Tanaka Norina, Tsukune Yutaka, Tanosaki Sakae, Ito Shigeki, Asayama Toshio, Sunakawa Mika, Kaito Yuta, Kuribayashi-Hamada Yasuko, Onodera Asaka, Moriya Keiichi, Komatsu Norio, Tanaka Junji, Odajima Takeshi, Sugimori Hiroki, Inokuchi Koiti, Tamura Hideto

Abstract excerpt

The signaling lymphocytic activation molecule family 3 (SLAMF3) is a member of the immunoglobulin superfamily expressed on T, B, and natural killer cells and modulates the activation and cytotoxicity of these cells. SLAMF3 is also expressed on plasma cells from patients with multiple myeloma (MM), although its role in MM pathogenesis remains unclear. This study found that SLAMF3 is highly and constitutively...

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PMID: 31974290
DOI: 10.1158/1541-7786.MCR-19-0391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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