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Article

Establishment and genomic characterization of a sporadic malignant peripheral nerve sheath tumor cell line.

Scientific reports - 11 Mar 2021

Longo Jody Fromm, Brosius Stephanie N, Znoyko Iya, Alers Victoria A, Jenkins Dorea P, Wilson Robert C, Carroll Andrew J, Wolff Daynna J, Roth Kevin A, Carroll Steven L

Abstract excerpt

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive Schwann cell-derived neoplasms that occur sporadically or in patients with neurofibromatosis type 1 (NF1). Preclinical research on sporadic MPNSTs has been limited as few cell lines exist. We generated and characterized a new sporadic MPNST cell line, 2XSB, which shares the molecular and genomic features of the parent tumor. These cells have a...

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Identifiers

PMID: 33707600
DOI: 10.1038/s41598-021-85055-2
PMCID: PMC7952412

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