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Article

Phenome-wide screening of GWAS data reveals the complex causal architecture of obesity.

Human genetics - 1 Aug 2021

García-Marín Luis M, Campos Adrián I, Kho Pik-Fang, Martin Nicholas G, Cuéllar-Partida Gabriel, Rentería Miguel E

Abstract excerpt

OBJECTIVE: In the present study, we sought to identify causal relationships between obesity and other complex traits and conditions using a data-driven hypothesis-free approach that uses genetic data to infer causal associations. METHODS: We leveraged available summary-based genetic data from genome-wide association studies on 1498 phenotypes and applied the latent causal variable method (LCV) between obesity and...

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PMID: 34057592
DOI: 10.1007/s00439-021-02298-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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