Phenome-wide screening of GWAS data reveals the complex causal architecture of obesity.

doi:10.1007/s00439-021-02298-9

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Article

Phenome-wide screening of GWAS data reveals the complex causal architecture of obesity.

Human genetics - 1 Aug 2021

García-Marín Luis M, Campos Adrián I, Kho Pik-Fang, Martin Nicholas G, Cuéllar-Partida Gabriel, Rentería Miguel E

Abstract excerpt

OBJECTIVE: In the present study, we sought to identify causal relationships between obesity and other complex traits and conditions using a data-driven hypothesis-free approach that uses genetic data to infer causal associations. METHODS: We leveraged available summary-based genetic data from genome-wide association studies on 1498 phenotypes and applied the latent causal variable method (LCV) between obesity and...

Topics

Body Mass Index
Cardiovascular Diseases
Female
Gastrointestinal Diseases
Genetic Association Studies
Genome-Wide Association Study
Genotype
Humans
Loneliness
Lung Diseases
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mental Disorders

Metabolic Diseases

Multifactorial Inheritance

Musculoskeletal Diseases

Obesity

Phenotype

Source

Open in PubMed

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PMID: 34057592
DOI: 10.1007/s00439-021-02298-9

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