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Article

Expression and Localization of AβPP in SH-SY5Y Cells Depends on Differentiation State

25 May 2021

Abstract excerpt

Neuroblastoma cell line SH-SY5Y, due to its capacity to differentiate into neurons, easy handling, and low cost, is a common experimental model to study molecular events leading to Alzheimer's disease (AD). However, it is prevalently used in its undifferentiated state, which does not resemble neurons affected by the disease. Here, we show that the expression and localization of amyloid-β protein precursor (AβPP),...

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PMID: 34057078
DOI: 10.3233/jad-201409

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