Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

sAPPalpha enhances the transdifferentiation of adult bone marrow progenitor cells to neuronal phenotypes.

Current Alzheimer research - 1 Feb 2006

Chen Chun-Wei David, Boiteau Rene M, Lai Wen-Fu Thomas, Barger Steven W, Cataldo Anne M

Abstract excerpt

The remediation of neurodegeneration and cognitive decline in Alzheimer's Disease (AD) remains a challenge to basic scientists and clinicians. It has been suggested that adult bone marrow stem cells can transdifferentiate into different neuronal phenotypes. Here we demonstrate that the alpha-secretase-cleaved fragment of the amyloid precursor protein (sAPPalpha), a potent neurotrophic factor, potentiates the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Antibodies
Share to Bone Marrow Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunohistochemistry

Share to Mice, Transgenic

Share to Nerve Growth Factors

Share to Neurons

Share to Stem Cells

Source

Identifiers

PMID: 16472205
DOI: 10.2174/156720506775697205

Genes

NGF
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

sAPPalpha enhances the transdifferentiation of adult bone marrow progenitor cells to neuronal phenotypes.PMID 16472205Read ↗

The temporal balance between self-renewal and differentiation of human neural stem cells requires the Amyloid Precursor ProteinSemantic proximity Read ↗

Precise Characterization of Differentiated SH-SY5Y Cells Using a Novel APP Splice Variant Dependent Method: for Intended Use in AD ResearchSemantic proximity Read ↗

Toxicity of Amyloid-β Peptides Varies Depending on Differentiation Route of SH-SY5Y CellsSemantic proximity Read ↗

Role of Cystatin C in Amyloid Precursor Protein-induced Proliferation of Neural Stem/Progenitor CellsSemantic proximity Read ↗

Cholinergic-like neurons carrying PSEN1 E280A mutation from familial Alzheimer's disease reveal intraneuronal sAPPβ fragments accumulation, hyperphosphorylation of TAU, oxidative stress, apoptosis and Ca2+ dysregulation: Therapeutic implications.Semantic proximity Read ↗

Expression and Localization of AβPP in SH-SY5Y Cells Depends on Differentiation StateSemantic proximity Read ↗

Ganglioside-Dependent Neural Stem Cell Proliferation in Alzheimer's Disease Model Mice.Semantic proximity Read ↗

Neurogenesis, NSCs, pathogenesis and therapies for Alzheimer's disease.Semantic proximity Read ↗

A novel APP splice variant-dependent marker system to precisely demarcate maturity in SH-SY5Y cell-derived neuronsSemantic proximity Read ↗

Effect of Soluble Amyloid Precursor Protein-alpha on Adult Hippocampal Neurogenesis in a Mouse Model of Alzheimer’s DiseaseSemantic proximity Read ↗

Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to beta-amyloid.Semantic proximity Read ↗

Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer's modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.