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Single-cell RNA sequencing identifies molecular targets associated with poorin vitromaturation performance of oocytes collected from ovarian stimulation

9 Apr 2021

Abstract excerpt

STUDY QUESTION: What is the transcriptome signature associated with poor performance of rescue IVM (rIVM) oocytes and how can we rejuvenate them? SUMMARY ANSWER: The GATA-1/CREB1/WNT signalling axis was repressed in rIVM oocytes, particularly those of poor quality; restoration of this axis may produce more usable rIVM oocytes. WHAT IS KNOWN ALREADY: rIVM aims to produce mature oocytes (MII) for IVF through IVM of...

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PMID: 34052851
DOI: 10.1093/humrep/deab100

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