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Single-cell multiomic analysis of in vivo and in vitro matured human oocytes

27 Feb 2020

Abstract excerpt

STUDY QUESTION: Are there any differences between in vivo (IVV) and in vitro (IVT) matured metaphase II (MII) oocytes at the molecular level? SUMMARY ANSWER: Between IVV and IVT oocytes, 507 differentially expressed genes (DEGs) were identified; the non-CpG methylomes were significantly different, but the CpG methylomes and genomic copy number variations (CNVs) were similar. WHAT IS KNOWN ALREADY: A previous...

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PMID: 32325493
DOI: 10.1093/humrep/deaa044

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