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Article

Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir

4 Apr 2019

Abstract excerpt

Remdesivir (GS-5734) is a 1'-cyano-substituted adenosine nucleotide analogue prodrug that shows broad-spectrum antiviral activity against several RNA viruses. This compound is currently under clinical development for the treatment of Ebola virus disease (EVD). While antiviral effects have been demonstrated in cell culture and in non-human primates, the mechanism of action of Ebola virus (EBOV) inhibition for...

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PMID: 30987343
DOI: 10.3390/v11040326

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