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Article

Unveiling the “Template-Dependent” Inhibition on the Viral Transcription of SARS-CoV-2

30 Jul 2022

Abstract excerpt

Remdesivir is one nucleotide analogue prodrug capable to terminate RNA synthesis in SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) by two distinct mechanisms. Although the "delayed chain termination" mechanism has been extensively investigated, the "template-dependent" inhibitory mechanism remains elusive. In this study, we have demonstrated that remdesivir embedded in the template strand seldom directly...

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PMID: 35912566
DOI: 10.1021/acs.jpclett.2c01314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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