Article
Assessment of intra-sample variability in HIV-1 DNA drug resistance genotyping.
The Journal of antimicrobial chemotherapy - 15 Jul 2021
Millière Laurine, Bocket Laurence, Tinez Claire, Robineau Olivier, Veyer Nathalie, Wojciechowski Fanny, Lambert Valérie, Meybeck Agnès, Huleux Thomas, Ajana Faiza, Hober Didier, Alidjinou Enagnon Kazali
Abstract excerpt
BACKGROUND AND OBJECTIVES: HIV-1 drug resistance testing can be performed in proviral DNA. The non-homogenous distribution of viral variants in cells can impact the performance of this method. We assessed the variability of HIV-1 DNA genotyping results in the same blood sample using a next-generation sequencing (NGS) method. METHODS: For each included patient, a blood sample from a single venipuncture was split...
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