Comparison of Different HIV-1 Resistance Interpretation Tools for Next-Generation Sequencing in Italy.

doi:10.3390/v16091422

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Comparison of Different HIV-1 Resistance Interpretation Tools for Next-Generation Sequencing in Italy.

Viruses - 6 Sept 2024

Armenia Daniele, Carioti Luca, Micheli Valeria, Bon Isabella, Allice Tiziano, Bonura Celestino, Bruzzone Bianca, Bracchitta Fiorenza, Cerutti Francesco, Giammanco Giovanni Maurizio, Stefanelli Federica, Bonifacio Maria Addolorata, Bertoli Ada, Vatteroni Marialinda, Ibba Gabriele, Novazzi Federica, Lipsi Maria Rosaria, Cuomo Nunzia, Vicenti Ilaria, Ceccherini-Silberstein Francesca, Rossetti Barbara, Bezenchek Antonia, Saladini Francesco, Zazzi Maurizio, Santoro Maria Mercedes

Abstract excerpt

BACKGROUND: Next-generation sequencing (NGS) is gradually replacing Sanger sequencing for HIV genotypic drug resistance testing (GRT). This work evaluated the concordance among different NGS-GRT interpretation tools in a real-life setting. METHODS: Routine NGS-GRT data were generated from viral RNA at 11 Italian laboratories with the AD4SEQ HIV-1 Solution v2 commercial kit. NGS results were interpreted by the...

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PMID: 39339898
DOI: 10.3390/v16091422
PMCID: PMC11437420

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Source receipt: pubmed, retrieved 7 Sept 2026.

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