Article
Cytokine Dysregulation in MECP2- and CDKL5-Related Rett Syndrome: Relationships with Aberrant Redox Homeostasis, Inflammation, and ω-3 PUFAs.
Oxidative medicine and cellular longevity - 1 Jan 2015
Leoncini Silvia, De Felice Claudio, Signorini Cinzia, Zollo Gloria, Cortelazzo Alessio, Durand Thierry, Galano Jean-Marie, Guerranti Roberto, Rossi Marcello, Ciccoli Lucia, Hayek Joussef
Abstract excerpt
An involvement of the immune system has been suggested in Rett syndrome (RTT), a devastating neurodevelopmental disorder related to oxidative stress, and caused by a mutation in the methyl-CpG binding protein 2 gene (MECP2) or, more rarely, cyclin-dependent kinase-like 5 (CDKL5). To date, it is unclear whether both mutations may have an impact on the circulating cytokine patterns. In the present study, cytokines...
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