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Cell Heterogeneity and Phenotypic Plasticity in Metastasis Formation: The Case of Colon Cancer

14 Sept 2019

Abstract excerpt

The adenoma-to-carcinoma progression in colon cancer is driven by a sequential accumulation of genetic alterations at specific tumor suppressors and oncogenes. In contrast, the multistage route from the primary site to metastasis formation is underlined by phenotypic plasticity, i.e., the capacity of disseminated tumor cells to undergo transiently and reversible transformations in order to adapt to the...

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PMID: 31540068
DOI: 10.3390/cancers11091368

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