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Article

Role of LYS271 and LYS279 residues in the interaction of cytochrome P4501A1 with NADPH-cytochrome P450 reductase.

Archives of biochemistry and biophysics - 15 Jan 2001

Cvrk T, Strobel H W

Abstract excerpt

It has been proposed that negatively charged amino acids on the surface of reductase and positively charged amino acids on the surface of P450 mediate the binding of both proteins through electrostatic interactions. In this study, we used a site-directed mutagenesis approach to determine a role for two lysine residues (Lys271 and Lys279) of cytochrome P4501A1 in the interaction of P4501A1 with reductase. We...

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Identifiers

PMID: 11368010
DOI: 10.1006/abbi.2000.2174

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