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Article

Global analysis of protein-protein interactions reveals multiple CYP2E1-reductase complexes.

Biochemistry - 4 Sept 2007

Jamakhandi Arvind P, Kuzmic Petr, Sanders Daniel E, Miller Grover P

Abstract excerpt

Although a single binary functional complex between cytochrome P450 (P450 or CYP for a specific isoform) and cytochrome P450 reductase (CPR) has been generally accepted in the literature, this simple model failed to explain the experimentally observed catalytic activity of recombinant CYP2E1 in dependence on the total concentration of the added CPR-K56Q mutant. Our rejection of the simplest 1:1 binding model was...

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Identifiers

PMID: 17685587
DOI: 10.1021/bi7003476
PMCID: PMC2592557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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