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Article

Relationships between accelerometer-measured and multiple sclerosis: a 2-sample Mendelian randomization study.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Aug 2021

Lu Hui, Wu Peng-Fei, Li Rui-Zhuo, Zhang Wan, Huang Guo-Xiang

Abstract excerpt

BACKGROUND: Observational studies suggest that physical activity (PA) can independently modify the risk of developing multiple sclerosis (MS). OBJECTIVE: To investigate the causal effect of PA on MS by Mendelian randomization (MR) approaches. METHODS: Through a genome-wide association study including 91,105 participants from UK Biobank, we obtained 5 single-nucleotide polymorphisms (SNPs) associated with...

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PMID: 33411191
DOI: 10.1007/s10072-020-04953-x

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