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Article

Accelerated aging in normal breast tissue of women with breast cancer.

Breast cancer research : BCR - 22 May 2021

Panjarian Shoghag, Madzo Jozef, Keith Kelsey, Slater Carolyn M, Sapienza Carmen, Jelinek Jaroslav, Issa Jean-Pierre J

Abstract excerpt

BACKGROUND: DNA methylation alterations have similar patterns in normal aging tissue and in cancer. In this study, we investigated breast tissue-specific age-related DNA methylation alterations and used those methylation sites to identify individuals with outlier phenotypes. Outlier phenotype is identified by unsupervised anomaly detection algorithms and is defined by individuals who have normal tissue...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34022936
DOI: 10.1186/s13058-021-01434-7
PMCID: PMC8140515

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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