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DNA-methylation age and accelerated epigenetic aging in blood as a tumor marker for predicting breast cancer susceptibility.

Aging - 5 Dec 2024

Jung Su Yon, Yu Herbert, Deng Youping, Pellegrini Matteo

Abstract excerpt

BACKGROUND: DNA methylation (DNAm)-based marker of aging, referred to as 'epigenetic age' or 'DNAm age' is a highly accurate multi-tissue biomarker for aging, associated with age-related disease risk, including cancer. Breast cancer (BC), an age-associated disease, is associated with older DNAm age and epigenetic age acceleration (age accel) at tissue levels. But this raises a question on the predictability of...

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Identifiers

PMID: 39642870
DOI: 10.18632/aging.206169
PMCID: PMC11723651

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