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Variants in Epithelial-Mesenchymal Transition and Immune Checkpoint Genes Are Associated With Immune Cell Profiles and Predict Survival in Non-Small Cell Lung Cancer.

Archives of pathology & laboratory medicine - 1 Oct 2020

Parra Edwin Roger, Jiang Mei, Machado-Rugolo Juliana, Yaegashi Lygia Bertalha, Prieto Tabatha, Farhat Cecília, de Sá Vanessa Karen, Nagai Maria Aparecida, de Lima Vladmir Cláudio Cordeiro, Takagaki Tereza, Terra Ricardo, Fabro Alexandre Todorovic, Capelozzi Vera Luiza

Abstract excerpt

CONTEXT.—: Identification of gene mutations that are indicative of epithelial-mesenchymal transition and a noninflammatory immune phenotype may be important for predicting response to immune checkpoint inhibitors. OBJECTIVE.—: To evaluate the utility of multiplex immunofluorescence for immune profiling and to determine the relationships among tumor immune checkpoint and epithelial-mesenchymal transition genomic...

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Identifiers

PMID: 32150457
DOI: 10.5858/arpa.2019-0419-OA

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