Article
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.
Nature communications - 28 Oct 2014
Chen Limo, Gibbons Don L, Goswami Sangeeta, Cortez Maria Angelica, Ahn Young-Ho, Byers Lauren A, Zhang Xuejun, Yi Xiaohui, Dwyer David, Lin Wei, Diao Lixia, Wang Jing, Roybal Jonathon, Patel Mayuri, Ungewiss Christin, Peng David, Antonia Scott, Mediavilla-Varela Melanie, Robertson Gordon, Suraokar Milind, Welsh James W, Erez Baruch, Wistuba Ignacio I, Chen Lieping, Peng Di, Wang Shanshan, Ullrich Stephen E, Heymach John V, Kurie Jonathan M, Qin F Xiao-Feng
Abstract excerpt
Immunosuppression of tumour-infiltrating lymphocytes (TIL) is a common feature of advanced cancer, but its biological basis has remained obscure. We demonstrate here a molecular link between epithelial-to-mesenchymal transition (EMT) and CD8(+) TIL immunosuppression, two key drivers of cancer progression. We show that microRNA-200 (miR-200), a cell-autonomous suppressor of EMT and metastasis, targets PD-L1....
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