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Two GWAS-identified variants are associated with lumbar spinal stenosis and Gasdermin-C expression in Chinese population.

Scientific reports - 3 Dec 2020

Jiang Hua, Moro Abu, Liu Yang, Wang Jiaqi, Meng Dihua, Zhan Xinli, Wei Qingjun

Abstract excerpt

The aim of this study is to investigate the expression levels of genome-wide association studies (GWAS)-identified variants near Gasdermin-C (GSDMC) and its association with lumbar disc degeneration (LDD) in a Chinese population. In accordance with previously reported findings, our study involved the top 4 variants; rs6651255, rs7833174, rs4130415, and rs7816342. A total of 800 participants, 400 LDD patients and...

Topics

Adolescent

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Adult

Asian People

Biomarkers, Tumor

Case-Control Studies

DNA-Binding Proteins

Female

Gene Frequency

Genetic Predisposition to Disease

Genome-Wide Association Study

Humans

Intervertebral Disc Degeneration

Intervertebral Disc Displacement

Lumbar Vertebrae

Male

Middle Aged

Polymorphism, Single Nucleotide

Spinal Stenosis

Source

Open in PubMed Open full text

Identifiers

PMID: 33273635
DOI: 10.1038/s41598-020-78249-7
PMCID: PMC7713291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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