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Article

CD34+CLDN5+ tumor associated senescent endothelial cells through IGF2-IGF2R signaling increased cholangiocellular phenotype in hepatocellular carcinoma.

Journal of advanced research - 1 Oct 2025

Zhu Xin-Yu, Liu Wen-Ting, Hou Xiao-Juan, Zong Chen, Yu Wei, Shen Zhe-Min, Qu Shu-Ping, Tao Min, Xue Meng-Meng, Zhou Dao-Yu, Bai Hao-Ran, Gao Lu, Jiang Jing-Hua, Zhao Qiu-Dong, Wei Li-Xin, Yang Xue, Han Zhi-Peng, Zhang Li

Abstract excerpt

INTRODUCTION: The heterogeneity of hepatocellular carcinoma (HCC) is linked to tumor malignancy and poor prognosis. Nevertheless, the precise mechanisms underlying the development of the cholangiocellular phenotype (CCA) within HCC remain unclear. Emerging studies support that the cross-talk among the host cells within tumor microenvironment (TME) sustains the cancer cell plasticity. OBJECTIVES: This study sought...

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Topics

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Share to Antigens, CD34
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Insulin-Like Growth Factor II

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Source

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Identifiers

PMID: 39674501
DOI: 10.1016/j.jare.2024.12.008
PMCID: PMC12793740

Genes

IGF2
IGF2R
CD34
CLDN5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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