Article
Cholangiocyte senescence caused by lysophosphatidylcholine as a potential implication in carcinogenesis.
Journal of hepato-biliary-pancreatic sciences - 1 Sept 2015
Shimizu Rina, Kanno Keishi, Sugiyama Akiko, Ohata Hiroki, Araki Anna, Kishikawa Nobusuke, Kimura Yasuhiro, Yamamoto Hiroya, Kodama Masanobu, Kihira Kenji, Tazuma Susumu
Abstract excerpt
BACKGROUND: The incidence of biliary tract cancer in patients with pancreaticobiliary maljunction or intrahepatic cholelithiasis is markedly high with undefined mechanism. In these diseases, biliary lysophosphatidylcholine (LPC) level is reportedly increased. This study investigated the influence of LPC on cholangiocytes focusing on cellular senescence and its potential contribution to carcinogenesis. METHODS:...
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