Article
A luciferase-based approach for measuring HBGA blockade antibody titers against human norovirus.
Journal of virological methods - 1 Nov 2021
van Loben Sels Jessica M, Meredith Luke W, Sosnovtsev Stanislav V, de Graaf Miranda, Koopmans Marion P G, Lindesmith Lisa C, Baric Ralph S, Green Kim Y, Goodfellow Ian G
Abstract excerpt
BACKGROUND: Noroviruses are the most common cause of viral gastroenteritis worldwide, yet there is a deficit in the understanding of protective immunity. Surrogate neutralization assays have been widely used that measure the ability of antibodies to block virus-like particle (VLP) binding to histo-blood group antigens (HBGAs). However, screening large sample sets against multiple antigens using the traditional...
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