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Article

Serological Correlate of Protection against Norovirus‐Induced Gastroenteritis

3 Sept 2010

Abstract excerpt

BACKGROUND: Norovirus infection is the leading cause of acute nonbacterial gastroenteritis. Histoblood group antigens (HBGAs) are host susceptibility determinants for Norwalk virus (NV) infection. We hypothesized that antibodies that block NV-HBGA binding are associated with protection from clinical illness following NV exposure. METHODS: We developed an HBGA blocking assay to examine the ability of human serum...

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PMID: 20815703
DOI: 10.1086/656364

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