Article
Gene-gene interactions between a LMNA variant and common polymorphisms drive early-onset atrial fibrillation.
Nature communications - 19 May 2026
Owais Asia, Chen Hanna, Farooq Hammad, Thami Prisca K, McGurk Kathryn A, Powell George J, DeSantiago Jaime, Abbas Talla, Sridhar Arvind, Pavel Arif, Webster Gregory, Merrill Bradley, Ware James S, Ng Fu Siong, Darbar Dawood
Abstract excerpt
Atrial fibrillation (AF), the most common sustained arrhythmia, has a complex genetic basis; however, the molecular mechanisms linking rare and common variants remain poorly understood. Polygenic risk score (PRS) analysis in the UK Biobank and All of Us cohorts reveals that carriers of protein-altering LMNA variants (PAVs) have a significantly higher risk of incident AF than predicted by PRS alone, supporting an...
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