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Article

The CCCTC-binding factor CTCF represses hepatitis B virus enhancer I and regulates viral transcription.

Cellular microbiology - 1 Feb 2021

D'Arienzo Valentina, Ferguson Jack, Giraud Guillaume, Chapus Fleur, Harris James M, Wing Peter A C, Claydon Adam, Begum Sophia, Zhuang Xiaodong, Balfe Peter, Testoni Barbara, McKeating Jane A, Parish Joanna L

Abstract excerpt

Hepatitis B virus (HBV) infection is of global importance with over 2 billion people exposed to the virus during their lifetime and at risk of progressive liver disease, cirrhosis and hepatocellular carcinoma. HBV is a member of the Hepadnaviridae family that replicates via episomal copies of a covalently closed circular DNA (cccDNA) genome. The chromatinization of this small viral genome, with overlapping open...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33006186
DOI: 10.1111/cmi.13274
PMCID: PMC7116737

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