Article
Molecular and immunohistochemical analysis of BRAF gene in primary cutaneous melanoma: Discovery of novel mutations.
Journal of cutaneous pathology - 1 Sept 2020
Fatnassi-Mersni Ghaya, Arfaoui Amira Toumi, Cherni Marwa, Jones Mariem, Zeglaoui Faten, Ouzari Hadda Imen, Rammeh Soumaya
Abstract excerpt
BACKGROUND: Determination of BRAF status is mandatory for targeted therapy but it is not currently available in most developing countries. AIM: We aimed to analyze BRAF mutations in a series of cutaneous melanoma of Tunisian patients and to compare BRAF V600E mutation detection by immunohistochemistry to DNA sequencing. PATIENTS AND METHODS: Archival formalin fixed paraffin embedded tissues from 28 patients with...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Child
- Developing Countries
- Female
- Humans
- Immunohistochemistry
- Male
- Melanoma
- Middle Aged
- Molecular Targeted Therapy
- Mutation
- Proto-Oncogene Proteins B-raf