Article
Computationally efficient whole-genome regression for quantitative and binary traits.
Nature genetics - 1 Jul 2021
Mbatchou Joelle, Barnard Leland, Backman Joshua, Marcketta Anthony, Kosmicki Jack A, Ziyatdinov Andrey, Benner Christian, O'Dushlaine Colm, Barber Mathew, Boutkov Boris, Habegger Lukas, Ferreira Manuel, Baras Aris, Reid Jeffrey, Abecasis Goncalo, Maxwell Evan, Marchini Jonathan
Abstract excerpt
Genome-wide association analysis of cohorts with thousands of phenotypes is computationally expensive, particularly when accounting for sample relatedness or population structure. Here we present a novel machine-learning method called REGENIE for fitting a whole-genome regression model for quantitative and binary phenotypes that is substantially faster than alternatives in multi-trait analyses while maintaining...
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