Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Obscurin: A multitasking giant in the fight against cancer.

Biochimica et biophysica acta. Reviews on cancer - 1 Aug 2021

Guardia Talia, Eason Matthew, Kontrogianni-Konstantopoulos Aikaterini

Abstract excerpt

Giant obscurins (720-870 kDa), encoded by OBSCN, were originally discovered in striated muscles as cytoskeletal proteins with scaffolding and regulatory roles. Recently though, they have risen to the spotlight as key players in cancer development and progression. Herein, we provide a timely prudent synopsis of the expanse of OBSCN mutations across 16 cancer types. Given the extensive work on OBSCN's role in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Methylation
Share to Epigenesis, Genetic
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Protein Serine-Threonine Kinases

Share to Rho Guanine Nucleotide Exchange Factors

Share to RNA, Antisense

Share to RNA, Long Noncoding

Source

Open in PubMed Open full text

Identifiers

PMID: 34015411
DOI: 10.1016/j.bbcan.2021.188567
PMCID: PMC8349851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Obscurin: A multitasking giant in the fight against cancer.PMID 34015411Read ↗

Unraveling obscurins in heart disease.Semantic proximity Read ↗

Multi-Omics Analysis Reveals OBSCN as a Key Modulator of Tumor Microenvironment, Microbial Signatures and Clinical Outcomes in Gastric Cancer.Semantic proximity Read ↗

Selective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordomaSemantic proximity Read ↗

Structural, molecular, and functional insights into Schlafen proteinsSemantic proximity Read ↗

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancerSemantic proximity Read ↗

Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band: implications for hereditary myopathies.Semantic proximity Read ↗

Novel OBSCN variants associated with a risk to exercise-intolerance and rhabdomyolysisSemantic proximity Read ↗

From Flies to Humans: A Conserved Role of CEBPZ, NOC2L, and NOC3L in rRNA Processing and TumorigenesisSemantic proximity Read ↗

All in the family: evidence for four new LEM-domain proteins Lem2 (NET-25), Lem3, Lem4 and Lem5 in the human genome.Semantic proximity Read ↗

Genomic Amplification and Functional Dependency of the Gamma Actin Gene ACTG1 in Uterine CancerSemantic proximity Read ↗

Identification, tissue expression and chromosomal localization of human Obscurin-MLCK, a member of the titin and Dbl families of myosin light chain kinasesSemantic proximity Read ↗

Networking in the nucleus: a spotlight on LEM-domain proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.