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Genomic Amplification and Functional Dependency of the Gamma Actin Gene ACTG1 in Uterine Cancer

18 Nov 2020

Abstract excerpt

Sarcomere and cytoskeleton genes, or actomyosin genes, regulate cell biology including mechanical stress, cell motility, and cell division. While actomyosin genes are recurrently dysregulated in cancers, their oncogenic roles have not been examined in a lineage-specific fashion. In this report, we investigated dysregulation of nine sarcomeric and cytoskeletal genes across 20 cancer lineages. We found that uterine...

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PMID: 33217970
DOI: 10.3390/ijms21228690

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