Article
Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band: implications for hereditary myopathies.
Journal of cell science - 1 Jun 2008
Fukuzawa Atsushi, Lange Stephan, Holt Mark, Vihola Anna, Carmignac Virginie, Ferreiro Ana, Udd Bjarne, Gautel Mathias
Abstract excerpt
Obscurin, a giant modular muscle protein implicated in G-protein and protein-kinase signalling, can localize to both sarcomeric Z-disks and M-bands. Interaction of obscurin with the Z-disk is mediated by Z-disk titin. Here, we unravel the molecular basis for the unusual localization of obscurin, a Z-disk-associated protein, to the M-band, where its invertebrate analogue UNC-89 is also localized. The first three...
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