Article
A novel germline mutation in SDHA identified in a rare case of gastrointestinal stromal tumor complicated with renal cell carcinoma.
International journal of clinical and experimental pathology - 1 Jan 2015
Jiang Quan, Zhang Yong, Zhou Yu-Hong, Hou Ying-Yong, Wang Jiong-Yuan, Li Jing-Lei, Li Ming, Tong Han-Xing, Lu Wei-Qi
Abstract excerpt
Succinate dehydrogenase (SDH), which is located on the mitochondrial inner membrane, is essential to the Krebs cycle. Mutations of the SDH gene are associated with many tumors, such as renal cell carcinoma, wild type gastrointestinal stromal tumors (WT GISTs) and hereditary paragangliomas/pheochromocytomas. Herein we present a rare case diagnosed as a WT GIST complicated with a renal chromophobe cell tumor and...
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