Article

Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylation

2019-03-05

Abstract excerpt

Histone H3 lysine 4 methylation (H3K4me) is extensively regulated by numerous writer and eraser enzymes in mammals. Nine H3K4me enzymes are associated with neurodevelopmental disorders to date, indicating their important roles in the brain. However, interplay among H3K4me enzymes during brain development remains largely unknown. Here, we show functional interactions of a writer-eraser duo, KMT2A and KDM5C , whic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eca931bb-1720-556f-9cc3-9b9e696cabc9
DOI: 10.1101/567917

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylationDOI 10.1101/567917Read

Functional convergence of histone methyltransferases EHMT1 and KMT2C involved in intellectual disability and autism spectrum disorder.Semantic proximity Read

<i>In-utero</i> rescue of neurological dysfunction in a mouse model of Wiedemann-Steiner syndromeSemantic proximity Read

Sexually Dimorphic Alterations in the Transcriptome and Behavior with Loss of Histone Demethylase KDM5C.Semantic proximity Read

Pathogenic variants in KMT2C result in a neurodevelopmental disorder distinct from Kleefstra and Kabuki syndromes.Semantic proximity Read

Expanding the phenotype associated to KMT2A variants: overlapping clinical signs between Wiedemann-Steiner and Rubinstein-Taybi syndromes.Semantic proximity Read

Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders.Semantic proximity Read

Histone Lysine Methylases and Demethylases in the Landscape of Human Developmental Disorders.Semantic proximity Read

KMT2A: Umbrella Gene for Multiple Diseases.Semantic proximity Read

KMT2C knockout generates ASD-like behaviors in miceSemantic proximity Read

Molecular insights of KMT2D and clinical aspects of Kabuki syndrome type 1.Semantic proximity Read

Patient Mutations of the Intellectual Disability Gene KDM5C Downregulate Netrin G2 and Suppress Neurite Growth in Neuro2a Cells.Semantic proximity Read

The Role of KDM2A and H3K36me2 Demethylation in Modulating MAPK Signaling During Neurodevelopment.Semantic proximity Read