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Changes of BDNF exon IV DNA methylation are associated with methamphetamine dependence.

Epigenomics - 1 Jun 2021

Iamjan Sri-Arun, Thanoi Samur, Watiktinkorn Paritat, Fachim Helene, Dalton Caroline F, Nudmamud-Thanoi Sutisa, Reynolds Gavin P

Abstract excerpt

Aim: We investigated DNA methylation of BDNF in methamphetamine (METH) dependence in humans and an animal model. Materials & methods:BDNF methylation at exon IV was determined by pyrosequencing of blood DNA from METH-dependent and control subjects, and from rat brain following an escalating dose of METH or vehicle. Bdnf expression was determined in rat brain. Results:BDNF methylation was increased in human METH...

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PMID: 34008409
DOI: 10.2217/epi-2020-0463

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