Methamphetamine-induced psychosis is associated with DNA hypomethylation and increased expression of AKT1 and key dopaminergic genes.

doi:10.1002/ajmg.b.32506

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Article

Methamphetamine-induced psychosis is associated with DNA hypomethylation and increased expression of AKT1 and key dopaminergic genes.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Dec 2016

Nohesara Shabnam, Ghadirivasfi Mohammad, Barati Mahmood, Ghasemzadeh Mohammad-Reza, Narimani Samira, Mousavi-Behbahani Zohreh, Joghataei Mohammadtaghi, Soleimani Mansoureh, Taban Mozhgan, Mehrabi Soraya, Thiagalingam Sam, Abdolmaleky Hamid Mostafavi

Abstract excerpt

Methamphetamine, one of the most frequently used illicit drugs worldwide, can induce psychosis in a large fraction of abusers and it is becoming a major problem for the health care institutions. There is some evidence that genetic and epigenetic factors may play roles in methamphetamine psychosis. In this study, we examined methamphetamine-induced epigenetic and expression changes of several key genes involved in...

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Identifiers

PMID: 27753212
DOI: 10.1002/ajmg.b.32506
PMCID: PMC7115129

Genes

AKT1
COMT
DRD3
DRD4
DRD1
DRD2
GAD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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