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Article

VGLL4 inhibits YAP1/TEAD signaling to suppress the epidermal squamous cell carcinoma cancer phenotype.

Molecular carcinogenesis - 1 Jul 2021

Mickle McKayla, Adhikary Gautam, Shrestha Suruchi, Xu Wen, Eckert Richard L

Abstract excerpt

Epidermal squamous cell carcinoma (SCC) develops in response to ultraviolet light exposure and is among the most common cancers. The transglutaminase 2 cancer cell survival protein stimulates the activity of the YAP1/TEAD transcription complex to drive the expression of genes that promote aggressive epidermal SCC cell invasion, migration, and tumor formation. Therefore, we are interested in mechanisms that may...

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Share to Adaptor Proteins, Signal Transducing
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Gene Expression Regulation, Neoplastic

Share to Skin Neoplasms

Share to Transcription Factors

Share to Xenograft Model Antitumor Assays

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Source

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Identifiers

PMID: 34004031
DOI: 10.1002/mc.23307
PMCID: PMC8243851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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