Article
ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma.
Oncogene - 20 Apr 2017
Hazawa M, Lin D-C, Handral H, Xu L, Chen Y, Jiang Y-Y, Mayakonda A, Ding L-W, Meng X, Sharma A, Samuel S, Movahednia M M, Wong R W, Yang H, Tong C, Koeffler H P
Abstract excerpt
ZNF750 controls epithelial homeostasis by regulating epidermal-differentiation genes, a role underscored by its pathogenic mutations in esophageal squamous cell cancers (SCCs). However, the precise role of ZNF750 in SCC cell biology remains unclear. In this study, we report that ZNF750 is exclusively deleted, mutated and underexpressed in human SCCs, and low ZNF750 expression is associated with poor survival....
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