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VGLL3 activates inflammatory responses by inducing interleukin‐1α secretion

22 Oct 2021

Abstract excerpt

Vestigial-like family member 3 (VGLL3), a member of the vestigial-like family, is a cofactor of the TEA-domain-containing transcription factor (TEAD). Although elevation in VGLL3 expression is associated with inflammatory diseases, such as inflammatory sarcomas and autoimmune diseases, the molecular mechanisms underlying VGLL3-mediated inflammation remain largely unknown. In this study, we analyzed the...

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PMID: 34679187
DOI: 10.1096/fj.202100679rr

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